Higher Tiam1 expression predicts good lymphatic metastasis and worse

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Caixia Yang,1 Chenlin Ma,1 Yingchun Li,1 Peng Mo,1 Yusheng Yangtwo

1Division of Stomatology, Qinghai province people’s Hospital, Qinghai, People’s Republic of China twoDivision of Pathology, Ninbo Yinzhou No. two Hospital, Ninbo, People’s Republic of China

Background: Numerous research have explored the prognostic worth of T-cell lymphoma invasion and metastasis inducing aspect 1 (Tiam1) and its association with lymphatic metastasis in malignant strong tumors, but the conclusions stay controversial. Thus, we performed a meta-evaluation to systematically assess the prognostic worth of Tiam1 expression and its association with lymphatic metastasis in malignant strong tumors.
Procedures: We searched eligible research in PubMed, Internet of Science and EMBASE databases (from inception up to October 2018). The combined HR with 95% CI was utilised to estimate the prognostic worth of Tiam1 expression. The correlation involving Tiam1 expression and lymphatic metastasis was assessed applying the combined odds ratio (OR) with 95% CI.
Benefits: A total of 17 research with two,228 individuals with strong tumors had been integrated in this meta-evaluation. The general estimated benefits showed that higher Tiam1 expression was considerably linked with shorter general survival (HR= 2.08, 95% CI: 1.62–2.68, P&lt0.01), and illness-no cost survival (HR = 1.86, 95% CI: 1.49–2.32, P&lt0.01). Apart from, we also identified that there was a close partnership involving higher Tiam1 expression and good lymphatic metastasis (OR=two.63 95% CI: 1.79–3.84, P&lt0.01).
Conclusion: Higher Tiam1 expression was considerably linked with shorter survival and good lymphatic metastasis in individuals with malignant strong tumors. Thus, Tiam1 could be a promising prognostic biomarker and an helpful therapeutic target for malignant strong tumors.

Keyword phrases: tumor, Tiam1, survival, meta-evaluation

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