OSacc: Gene Expression-Primarily based Survival Evaluation Net Tool For Adrenocort

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Longxiang Xie,1 Qiang Wang,1 Fangmei Nan,1 Linna Ge,1 Yifang Dang,1 Xiaoxiao Sun,1 Ning Li,1 Huan Dong,1 Yali Han,1 Guosen Zhang,1 Wan Zhu,two Xiangqian Guo1

1Bioinformatics Division of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, College of Application, College of Fundamental Health-related Sciences, Henan University, Kaifeng 475004, People’s Republic of China twoDivision of Anesthesia, Stanford University, Stanford, CA, USA

Correspondence: Xiangqian Guo
Bioinformatics Division of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, College of Application, College of Fundamental Health-related Sciences, Henan University, Kaifeng 475004, People’s Republic of China
Tel +86-371-23880585
E-mail [email protected]

Abstract: Gene expression profiling information with lengthy-term clinical adhere to-up facts are wonderful sources to screen, create, evaluate and validate prognostic biomarkers in translational cancer analysis. Even so, an quick-to-use interactive on the net tool is necessary to analyze these profiling and clinical information. In the present operate, we created OSacc (On line consensus Survival evaluation of ACC), a net tool that offers speedy and user-friendly survival evaluation primarily based on seven independent transcriptomic profiles with lengthy-term clinical adhere to-up facts of 259 ACC sufferers gathered from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. OSacc enables researchers and clinicians to evaluate the prognostic worth of genes of interest by Kaplan–Meier (KM) survival plot with hazard ratio (HR) and log-rank test in ACC. OSacc is freely readily available at http://bioinfo.henu.edu.cn/ACC/ACCList.jsp.

Keywords and phrases: ACC, prognostic marker, more than survival, net tool, KM plot

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